Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study

Purpose: Evaluation of the effect platelet-rich plasma (PRP) containing platelet-derived growth factor on in vitro fertilization (IVF) failure patients. Methods: In this clinical trial, 80 eligible patients (infertile women with at least two IVF failures) were randomly assigned into groups, including who received an intrauterine infusion PRP (n: 40) and controls 40). Before therapy, standard hormone replacement therapy was performed for all to endometrial thickness preparation. After sonographic assessment endometrium, injected patients’ endometrium whether they had appropriate or not. Then, embryo transferring done through IVF. Eventually, consequences fertility, implantation, pregnancy evaluated. Data analysis using SPSS version 22. Results: The rate successful [6 (15%)], [5 (12.5%)], live birth (12.5%)] relatively higher undergoing compared [2 (5%), 1 (2.5%) 0, respectively]. However, their statistical difference not significant between groups (P > 0.05). Conclusion: Our findings suggest that injection did significantly improve process, pregnancy, rates.